Wei-Hao Zhao

Bio-inspired helical microcarriers anchoring quercetin nanoparticles enable prolonged and self-trackable colonic delivery in colitis

Oral antioxidant therapy for Inflammatory Bowel Disease (IBD) is currently hampered by the “oral delivery paradox”, wherein the therapeutic potential of bioactive agents is compromised by poor aqueous solubility and rapid gastrointestinal washout. To overcome these biopharmaceutical barriers, we engineered a bio-in...