Wei-Hu Ma

NEAT1_1-encoded microprotein PSNEAT1 drives rDNA transcription via phase separation with WRN.

Nuclear enriched abundant transcript 1 (NEAT1) has two isoforms that serve as core structural components of paraspeckles. Although the regulatory functions of NEAT1 as a noncoding RNA are well established, it has remained unclear whether the short polyadenylated isoform, NEAT1_1, encodes a functional microprotein. Here...