Wei-Jun Huang

Paclitaxel-erianin prodrug self-assembled nanoparticles mediate a positive feedback loop of ferroptosis and immunity in breast cancer.

Breast cancer chemotherapy is hindered by multiple therapeutic challenges, including tumor immune evasion and ferroptosis resistance. Herein, we design and synthesize carrier-free prodrug self-assembled nanoparticles (PSSE NPs) with an ultrahigh drug-loading capacity. In response to the high intracellular glutathione (...