Wei-Kai Wu

Gut microbial phenylalanine metabolism contributes to MASLD in a dietary protein-dependent manner

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects nearly a third of adults worldwide, yet how diet shapes the microbiota’s contribution remains unclear. In a diet-induced mouse model varying protein content independently of caloric intake, microbiota depletion ameliorated hepatic steatosis and li...