Author

Wei Lin

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Jul 2026

USP20-mediated PGAM1 stabilization promotes glycolysis and confers osimertinib resistance in non-small cell lung carcinoma

This study shows that elevated USP20 expression drives osimertinib resistance and is associated with poor clinical outcomes in osimertinib-resistant NSCLC, and identifies compound 89131-02-2 as a novel and selective inhibitor that targets the USP20 C154 catalytic site.

Yunchong Meng, Xiaojun Wang, Shihao Wu et al. · Oncogene · 0 citations