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Open access Oct 2026

PSHIC reveals allele-specific chromatin organization by phasing-free structural modeling

Resolving the distinct 3D chromatin architectures of parental chromosomes is critical for understanding diploid genome function, but many haplotype-resolved Hi-C contact-map methods remain constrained by their reliance on phased single-nucleotide polymorphisms (SNPs). This dependency treats reconstruction as a simple t...

Wei Liu, Xue-Ying Wang, Yu-Wei Zhang et al. · 0 citations

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