Open access
Jul 2026
Mucosal boosting of chimpanzee adenovirus-vectored vaccine encoding SARS-CoV-2 RBD-heterodimer provides robust protection in mice
A chimpanzee adenovirus (AdC68)-vectored vaccine expressing the Delta-XBB receptor-binding domain (RBD)-dimer is constructed and comprehensively compared the immune responses induced by intramuscular injection, intranasal administration, or aerosol inhalation, revealing that aerosol inhalation provided significantly be...
Xue-Yuan Liu, Yaling An, Huixin Duan et al.
· mBio · 0 citations