Oct 2026
Design, synthesis, and biological evaluation of novel dual-functional NMT/IDO-1 inhibitors with fungicidal and immunomodulatory activities.
Invasive fungal infections, particularly those caused by fluconazole- resistant strains, remain a major clinical challenge owing to the limited therapeutic options currently available and the immunosuppressive state induced by the infection. Herein, we report the rational design of a series of dual-targeting small mole...
Ya-Ting Liu, An-Li Zhang, Chang-Ming Li et al.
· Bioorganic chemistry (Print) · 0 citations