Integration of network pharmacology and metabolomics to elucidate Qi-Xiong-Qu-Yu decoction mitigates myocardial ischemia via regulating Nrf2/ROS/MAPK signaling
Background: Qi-Xiong-Qu-Yu decoction (QXD) is an empirical herbal formula developed for the clinical treatment of ischemic heart disease. Methods: Isoproterenol (ISO) was used to establish a rat model of myocardial ischemia, and the effects of QXD were evaluated. The chemical profile of QXD was identified using UPLC-Q-...