Author

Wei-Ping Li

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Open access Sep 2026

CGP60474, a novel MITD1-targeted inhibitor for bladder cancer progression via CDK4/cyclin D1 pathway modulation

Targeted therapy holds promise for advanced bladder cancer, but its development is limited by a lack of therapeutic targets. Here, we show that MITD1 is elevated in bladder cancer and associated with poor patient prognosis. We find that MITD1 drives cancer progression by interacting with the CDK4/cyclin D1 complex to...

Suo-Shi Jing, En-Guang Yang, Xin-Yu Zhang et al. · Communications Biology · 0 citations

Open access Sep 2026

A Prognostic Model for Prostate Cancer Screened from Stress Granule-Related Genes: An Integrated Bioinformatic Analysis and Experimental Verification of SPAG5 Function

Experimental data linking this model to the immune microenvironment and epithelial differentiation support the notion that SPAG5 is an oncogenic factor, suggesting that SPAG5 warrants further investigation as a potential prognostic biomarker, though prospective validation is required before clinical translation.

Zi-Tong Qin, Ting Wang, Run-Zhang Liu et al. · Biomedicines · 0 citations

Open access Sep 2026

Unraveling tumor cell heterogeneity and epithelial-mesenchymal plasticity in gastric adenocarcinoma: an integrative multi-omics framework evaluating PVR/CD155 as a tumor cell-intrinsic EMT-associated target

A large-scale, multi-layered analytical pipeline connects single-cell resolution with spatial and histological data, produces validated prognostic tools and nominates PVR/CD155 as a tumor cell-intrinsic EMT-associated target candidate for gastric cancer.

Jian-Wen Li, Zi-Tong Qin, Ting Wang et al. · Frontiers in Immunology · 0 citations