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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Wei-Qi Qiu

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Open access Sep 2026

Development of m6A Readers for Enhanced Recognition In Vitro via Genetic Code Expansion

The YTH domain was recently demonstrated as a promising tool for recognizing and regulating m6A-modified RNAs. However, the deficiency in binding affinity (micromolar range) and selectivity (off-target binding) for m6A of the wild-type YTH domain limit its sensitivity and accuracy for m6A recognition. Engineering strat...

Michael S. Addo, Elise D. Ficaretta, Yi-Bo Chang et al. · 0 citations
Jul 2026

Fluorogenic RNA Aptamer-Based Activity Quantification of T7 RNA Polymerase.

T7 RNA polymerase (T7 RNAP) is a central molecular biology tool that is broadly used for biomedical research and the RNA therapeutic industry. T7 RNAP and its engineered variants provide valuable tools in synthetic biology and gene expression regulation. T7 RNAP activity unit is traditionally quantified by a radioactiv...

Khalil Mimouni, Wei-Qi Qiu, Hui-Qing Zhou · 0 citations

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