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Open access Sep 2026

Improving the Early Detection of Hepatocellular Carcinoma in Patients with Chronic Liver Disease: An Integrated C-GALAD Model and Cell-Free DNA Approach.

Background/Aims Chronic liver disease (CLD) confers an increased risk of hepatocellular carcinoma (HCC), but individual biomarkers have limited diagnostic performance, necessitating a combined approach. The study aimed to evaluate the value of a combined strategy integrating the C-GALAD (gender, age, lens culinaris agg...

Jian-Sheng Chen, Bao-Quan Yan, Xiao-Mei Liu et al. · 0 citations
Review Open access Oct 2026

Omics-derived signatures in metabolic dysfunction-associated steatotic liver disease: from molecular characterization to clinical translation

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent systemic metabolic disorder with heterogeneous clinical trajectories. Although liver biopsy remains the histological reference standard, its invasiveness and limited scalability restrict routine use, while established non-invasive te...

Zi-Yan Qin, Dulguun Juramt, Yu-Guo Chen et al. · 0 citations
Open access Sep 2026

An inflammation-nutrition-surgery-based INSEP model and a web-based clinical decision support system for predicting early postoperative infection in elderly patients with hepatocellular carcinoma: a multicenter retrospective study

The INSEP model is a reliable and practical tool for individualized EPI risk assessment in elderly HCC patients undergoing curative hepatectomy, demonstrating good predictive performance, clinical applicability, and user acceptability.

Guang-Zhao Shao, Dian-Dian Hao, Fei-Xiang Luo et al. · 0 citations

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