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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Wei-Rui Ma

h-index 9 View on Semantic Scholar

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Open access Aug 2026

Codon optimization depletes stop codons in alternative reading frames of protein-coding nucleic acid therapeutics.

Analysis of 120 therapeutic sequences, including FDA-approved COVID-19 messenger RNA (mRNA) vaccines, confirms widespread -1 frame stop codon depletion and establishes stop codon distribution as a critical design parameter for protein-coding nucleic acid therapeutics.

Zheling Liu, Zhenguang Ying, Luoan Shen et al. · 0 citations

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