Author

Wei-Sheng Guo

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Oct 2026

Immunoregulatory artificial lymph nodes restore antigen-specific tolerance in advanced multiple sclerosis.

Tolerogenic dendritic cell (tolDC) vaccines are a promising antigen-specific therapy for multiple sclerosis (MS), yet their efficacy is limited by poor homing to secondary lymphoid organs and rapid loss of the tolerogenic phenotype in native inflamed lymph nodes. Here, we developed a 3D-printed tolerogenic artificial l...

Jing-Sen Ji, Xin-Huan Wang, Lu Liu et al. · Science Translational Medici... · 0 citations

Review Open access Jul 2026

Nanomaterials Drive In Vivo CAR Immune Cells Engineering.

The intrinsic trade-off between therapeutic durability and biosafety across distinct delivery platforms is discussed, along with the necessity that their clinical translation hinges on systematic optimization of delivery precision, immune compatibility, and expression controllability.

Meifen Luo, Kai Liao, Jinxi Chang et al. · Advances in Materials · 0 citations