Integrative multi-omics reveals a prognostic and therapeutic landscape of synthetic lethality-associated signatures in lung adenocarcinoma
This work integrated single-cell RNA sequencing, spatial transcriptomics, and machine learning to characterize synthetic lethality (SL)-associated transcriptional activity in Lung adenocarcinoma and identified 13 high-SL signature genes, with IFRD2 (interferon-related developmental regulator 2) among the top contributo...