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Open access Aug 2026

Methyltransferase-assisted single duplex sequencing for detecting circulating tumor DNA

Accurate circulating tumor DNA (ctDNA) detection is limited by high sequencing errors. To address this, we developed Methyltransferase-Assisted Single Duplex sequencing (MASD-seq), which physically links Watson and Crick strands to enable error correction using double-stranded information within a single read pair. MAS...

Zhao-Yu Jiang, Yuxuan Wu, Yu-Qing Guo et al. · 0 citations

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