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Author

Wei-Wei Guo

2 papers indexed here

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Sep 2026

A Click-Triggered Bioorthogonal Strategy for Dual Activation of Covalent Warheads and Reporter Payloads

Michael acceptors are indispensable electrophilic motifs in chemical biology and covalent drug discovery, yet their intrinsic “always-on” reactivity frequently causes off-target modification and limits therapeutic precision. Here we report a bioorthogonal strategy for externally controlling Michael acceptor reactivit...

Xiao-Wei Xu, Yang-Fei Shi, Yan Zhao et al. · 0 citations
Open access Aug 2026

Tunable and self-reporting esterase-activated cyanide prodrugs exert cytoprotective effects

Hydrogen cyanide (HCN) is increasingly recognized as a mammalian gasotransmitter with biphasic biological effects, but its study is limited by the lack of controllable delivery tools. Here we report esterase-activated, self-reporting cyanide donors with tunable release kinetics and fluorogenic readout. Upon esterase ac...

Xi-Dan Tong, Wen Peng, Jin-Ru Feng et al. · 0 citations

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