Open access
Aug 2026
Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs
ABSTRACT Background and Aims Tumors actively remodel the tumor microenvironment (TME) to foster therapy resistance. However, the underlying mechanisms remain poorly defined. This study aims to characterize how colorectal cancer (CRC) cells drive TME remodeling to promote radioresistance. Methods A radioresistant CRC ce...
Yimin Fang, Jinglin Zhu, Qian Xiao et al.
· Advancement of science · 0 citations