Platelet glycoprotein VI in platelet-neutrophil interactions: From complex formation to neutrophil extracellular trap-associated pathology.
Platelets and neutrophils form dynamic platelet-neutrophil complexes (PNCs) that connect vascular injury with inflammatory effector responses. Glycoprotein VI (GPVI), a platelet-restricted immunoreceptor, converts collagen- and fibrin-related cues into ITAM signaling, granule secretion and integrin activation. GPVI is...