BACKGROUND
The increasing prevalence of phytopathogenic oomycetes and bacteria, particularly Phytophthora capsici (Pc) and Xanthomonas oryzae pv. oryzae (Xoo), poses severe threats to global agricultural production. Developing novel antimicrobial agents with dual antimicrobial activities, multiple mechanisms of action,...
Fang Tian, Jun-Rong Song, Ming-Man Sun et al.· Pest Management Science· 0 citations
BACKGROUND
Plant pathogenic fungi and bacteria cause substantial losses in agricultural production worldwide, and escalating resistance to conventional agrochemicals necessitates the development of novel, environmentally benign pesticides. Formononetin, a naturally occurring isoflavone, exhibits promising bioactivities...
Xiao-Yan Pan, Jun-Rong Song, Qing-Xue Hu et al.· Pest Management Science· 0 citations
Global agricultural production relies heavily on chemical pesticides, leading to resistance, residues, and pollution, threatening sustainable agriculture. There is an urgent need to develop novel antimicrobial agents from low-toxicity, easily degradable natural products. Using formononetin as a lead compound, acylpip...
Fang Tian, Miao-He Zhang, Qing-Xue Hu et al.· Journal of Agricultural and...· 0 citations
BACKGROUND
The persistent proliferation of bacterial phytopathogens presents a significant threat to global food security and agricultural sustainability. Among these pathogens, species belonging to the genus Xanthomonas are particularly destructive. Xanthomonas oryzae pv. oryzae (Xoo), the causal agent of bacterial le...
Yu-Guo Zheng, Mei-Hang Chen, Hua Sun et al.· Pest Management Science· 0 citations
A series of thiazolidinedione derivatives containing thioamide and piperidine moieties were designed, synthesized, and evaluated for antifungal activity against plant pathogenic fungi. Several compounds exhibited potent antifungal activity, among which Z17 was the most active against Rhizoctonia solani (EC50 = 1.8 μg/m...
Junrong Song, Shuang Feng, Miaohe Zhang et al.· Journal of Agricultural and...· 0 citations
In vivo antifungal assays conducted on rice leaves and kiwifruit demonstrated that X4 displayed satisfactory protective and curative effects, and molecular docking experiments combined with SDH activity assays indicated that X4 engages in favorable interactions with SDH.
Xiao-Yan Pan, Dan Shen, Han Yang et al.· Journal of Agricultural and...· 0 citations
Findings indicate that H7 could serve as a lead compound for the development of novel fungicides against kiwifruit soft rot and preliminary mechanistic investigations suggested that the antifungal activity of H7 is associated with disruption of cell membrane integrity and inhibition of succinate dehydrogenase activity.
Qing-Xue Hu, Xiao-Ting Geng, Xiao-Yan Pan et al.· Molecular diversity· 0 citations
Although the precise molecular target remains unknown, H2 shows promise as a lead candidate, and the benzothiazole moiety appears critical for enhancing activity, and the preliminary basis for developing eco-friendly fungicides is provided.
Dan Shen, Xiaoyan Pan, Han Yang et al.· Journal of Agricultural and...· 0 citations
Mechanistic studies revealed that Q8 disrupted cell membrane integrity and inhibited succinate dehydrogenase (SDH) activity, with computational simulations suggesting a higher binding affinity for SDH than fluopyram.
Qing-Xue Hu, Xiao-Ting Geng, Fang Tian et al.· Journal of Agricultural and...· 0 citations
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