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Sep 2026

In vivo CRISPR screens identify the glutamine transporter SLC1A5 as a metabolic barrier to antitumor immunity.

Tumor cells often evade immune pressure via metabolic reprogramming, yet the key metabolic regulators orchestrating this process remain incompletely defined. Here, using in vivo metabolic CRISPR screening under distinct immune pressures, we identified tumor cell-intrinsic solute carrier family 1 member 5 (SLC1A5) as a...

Wen-Long Jia, Guan-Xing Yu, Shen-Qi Han et al. · 0 citations
Open access Sep 2026

Guanine promotes acute lung injury by repressing H3K27me3 in sepsis.

Sepsis is systemic inflammation with high mortality, accompanied by multi-organ failure including acute respiratory distress syndrome. Extracellular vesicles (EVs) encapsulating bioactive cargoes, mediate cell-cell communication to exert systemic regulation. However, whether and how host lung tissue responds quickly to...

Chao-Qun Wang, Hui-Juan Wang, Yue-Yu Kong et al. · 0 citations

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