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UBA2-Mediated Sumoylation Is Required for Both Spermatocyte and Sertoli Cell Functions During Mouse Spermatogenesis.
BACKGROUND SUMO proteins are highly expressed in testicular cells, including spermatocytes and Sertoli, where they modify numerous proteins. Nonetheless, the role of SUMO proteins in spermatogenesis in vivo has remained unconfirmed. OBJECTIVES To confirm the requirement for sumoylation in the mouse in vivo during mei...