Phagocytic synapse enhancers are developed, a class of modular immune engagers comprising a high-affinity PD-L1 binder coupled to a macrophage-stimulating peptide, tuftsin, that provides a blueprint for a plug-and-play platform of immune engagers targeting diverse cancer-associated pathways.
Valerio Sabatino, Cong Tang, Rita C. Acúrcio et al.· Cancer Research· 0 citations
Irreversible covalent inhibitors have garnered significant attention in recent years. Despite encouraging progress, the vast majority contain electrophiles that target the least abundant amino acid cysteine, substantially limiting target inhibitor design for therapeutic intervention. Here, we generalize 2-ethynylbenzal...
Paul M. Levine, Patrick W. Erickson, Timothy W. Craven et al.· ACS Chemical Biology· 0 citations
Three-dimensional protein crystals are ordered, porous macroscopic materials with potential applications in catalysis, biosensing, and biomedicine. However, most protein crystals are obtained by empirical screening, providing limited control over the lattice architecture, pore geometry or component composition that det...
Zhe Li, Shun-Zhi Wang, W. Sheffler et al.· bioRxiv· 0 citations
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