Open access
Sep 2026
An NLRP3 inflammasome–anchored Astragalus mechanistic prior yields a mortality-associated transcriptomic signal in ICU sepsis: a secondary analysis with exploratory cross-cohort assessment
We developed ASTRA, a literature-informed, author-defined Astragalus mechanistic prior, and examined whether integrated and node-level whole-blood transcriptomic scores were associated with 28-day mortality in ICU sepsis. The primary analysis included 479 adults with sepsis from GSE65682; an exploratory cross-cohort di...
Xiao-Juan Yang, Tian-Tian Hu, Jia-Li Wang et al.
· Inflammation Research · 0 citations