OBJECTIVE
Systemic lupus erythematosus (SLE) is an autoimmune disease closely associated with enzyme dysfunction, yet its underlying molecular mechanisms remain incompletely understood. This study aims to characterize enzyme-network alterations associated with SLE status and disease activity and to identify candidate m...
Introduction: Low-grade glioma (LGG), defined herein as WHO grade II and III diffuse gliomas including astrocytomas and oligodendrogliomas, is a clinically and molecularly heterogeneous group of primary brain tumors with variable outcomes, highlighting the need for reliable prognostic biomarkers and immune-related ther...
Jia-Yu Gu, Zhi-Qiang He, Sheng-Nan He et al.· Eurasian Journal of Medicine...· 0 citations
This integrative multi-omics study identifies inflammatory and interferon-dominated molecular alterations in SLE PBMCs that overlap with aging-related biological processes and converge on shared regulatory networks.
Hong-Wei Zeng, Donge Tang, Yong Dai et al.· Frontiers in Immunology· 0 citations
ST6GAL1-mediated α2,6-sialylation of EGFR contributes to the maintenance of CSLC-associated paclitaxel resistance through mTOR-SOX2/BMI1 signaling, which identifies ST6GAL1-dependent EGFR sialylation as a potential therapeutic target in CSLC-associated chemoresistance.
Yu-Xi Yang, Bing-Hui Liang, W. Hong et al.· Cancer Drug Resistance· 1 citation
This study provides a systematic multi-omics characterization of immune microenvironment remodelling in CRC and identifies candidate molecular regulators that may serve as potential targets for future immunotherapy research.
Hong-Wei Zeng, Lie-Wen Lin, Yumei Chen et al.· Cancer Genomics & Proteomics· 0 citations
It is suggested that MAPK/ERK signaling contributes to the transition from adaptive tolerance to stable resistance to afatinib and highlight a tractable therapeutic vulnerability for overcoming resistance to tyrosine kinase inhibitors in NSCLC.
