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Author

Wei Zhang

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Aug 2026

Inhibition of nucleoporin 214 depletes leukemia stem cells by promoting heme catabolism and lipid peroxidation.

Chromosomal translocations involving nucleoporin (NUP) loci, such as NUP98 and NUP214, are recurrent in acute myeloid leukemia (AML). However, the intrinsic functions of wild-type nucleoporins in AML remain largely unknown. By screening the NUP family, we identified NUP214 as a frequently overexpressed gene and a criti...

Zhe Chen, Feng Wu, Wei Zhang et al. · 3 citations
Review Open access Aug 2026

Engineered MSC-exosomes as CRISPR-Cas9 delivery vectors for precision immunotherapy

This review presents a comprehensive analysis of strategies for engineering MSC-Exos as delivery vehicles for CRISPR-Cas9, with emphasis on cargo-loading methodologies and surface modifications that enable targeting specific immune cell populations.

Dan-Dan Guo, Wei Zhang, Wen-Bo Dou et al. · 0 citations

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