Spatial gradients of nigral magnetic susceptibility in de novo and medicated Parkinson's disease.
OBJECTIVES Aberrant iron accumulation in the substantia nigra (SN) is implicated in Parkinson's disease (PD), but spatial gradients of magnetic susceptibility (χ) in PD remain unclear. This study aimed to quantify χ gradients of the SN across different stages of PD. METHODS Twenty-one de novo PD (dnPD) patients, 27 m...