Wei-Zheng Zhang

Exercise as a multisystem signaling therapy: A hypothesis integrating inter-organ communication and membrane microdomain regulation in metabolic disease.

Exercise is a powerful non-pharmacological intervention for metabolic diseases, yet current mechanistic explanations remain fragmented across individual organs. This review proposes that exercise may act as a multisystem signaling therapy, generating interdependent mechanical, endocrine, metabolic, inflammatory, and re...