Author

Weicheng Huang

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Preprint Jul 2026

Chamaileon: Cross-Context Binder Design with Contextualized Modeling and Mixed Sampling

Chamaileon is introduced, which unifies multi-target and multi-state binder design by formulating the problem as cross-context binding landscape modeling and effectively generates sequences adaptable to diverse conformational landscapes and multi-target requirements.

Hengyuan Cao, Shizhuo Cheng, Mingxuan Liu et al. · 0 citations