Open access
Aug 2026
Fto-mediated m6A demsupplementethylation of SNHG9 Enhances PINK1-Dependent mitophagy and reverses cisplatin resistance via nuclear EZH2 ubiquitination.
Findings reveal a previously underappreciated mechanism of CDDP resistance driven by the FTO/SNHG9/VHL/EZH2/PINK1/Parkin axis and support the therapeutic potential of targeting this pathway in LUAD.
Zihan Jing, Xingmei Ren, Ruqiong Wang et al.
· Biochemical Pharmacology · 0 citations