Review
Open access
Aug 2026
The role of fumarate and itaconate in tumor microenvironment.
In recent years, the mechanisms of abnormal metabolite accumulation in tumor development have become an emerging research field. Cells within the tumor microenvironment (TME) sustain tumor proliferation via metaboalic reprogramming. Such metabolic remodeling triggers aberrant oncometabolite accumulation, which drives t...
Yi-Dan Fan, Han-Qiu Zhang, Jinkun Qin et al.
· Seminars in Oncology · 0 citations