Wenbin Lin

Bifunctional Metal-Organic Frameworks Integrate Energy- and Electron-Transfer Pathways for Enhanced Photodynamic Therapy.

Metal-organic frameworks (MOFs) have emerged as promising nanophotosensitizers for photodynamic therapy (PDT), but most reported systems rely predominantly on a single O2-activation pathway, limiting their ability to produce complementary reactive oxygen species (ROS). Herein, we report a bifunctional MOF, Hf-VIO-DBP,...

Metal-organic framework nanovaccines for systemic tumour regression.

siRNA-Loaded Metal-Organic Layers for Targeted Gene Silencing and Radiotherapy Enhancement.

Radiotherapy (RT) remains a cornerstone in cancer treatment; however, its therapeutic efficacy is often limited by tumor fibrosis and radioresistance, primarily driven by transforming growth factor-β (TGF-β) upregulation. To address these challenges, we developed a tris(bipyridyl)ruthenium(II)-based metal-organic layer...