Author

Wen-Bin Yao

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Open access Aug 2026

NKAIN1 predicts poor prognosis and associated with drug resistance and immune infiltration in prostate adenocarcinoma

NKAIN1 was significantly upregulated in PRAD, correlating with advanced TNM stages, poor survival, and may be involved in drug resistance, and high NKAIN1 expression was associated with altered immune infiltration and NKAIN-related genes were enriched in Wnt signaling, metabolism, and immune-related pathways.

Xuan-Cai Chen, Cong Wang, Xing-Ming Qu et al. · BMC Cancer · 0 citations

Open access Jul 2026

Integrated single-cell and spatial transcriptomics reveals a multicellular program contributing to immunotherapy resistance and adverse clinical outcomes in clear cell renal cell carcinoma.

This study defines a spatially organized, functionally coordinated multicellular niche that drives ICB resistance in ccRCC, establishing both a predictive biomarker for patient stratification and a mechanistic framework for therapeutic intervention.

Wen-Bin Yao, Jia Qi, Xinyi Zheng et al. · npj Precision Oncology · 0 citations