Author

Wencan Wu

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Open access Oct 2026

A circRNA-microRNA-Pdcd1 axis drives microglial activation and retinal ganglion cell degeneration

Retinal ganglion cell (RGC) degeneration is the primary cause of vision loss, driven by the complicated effects of intrinsic neuronal damage and neuroinflammation. However, current single-target therapies fail to address these dual pathological challenges. CircRNAs, functioning through ceRNA networks, represent a m...

Lan-Fang Sun, Xiao-Yu Ke, J.-J. Yu et al. · Communications Biology · 0 citations

Open access Jul 2026

A peripheral subpopulation of retinal pigment epithelium resists oxidative damage through SERPINE3-mediated caspase-1 inhibition

A peripheral RPE subpopulation is identified through spatial, transcriptomic, and functional analyses, thereby contributing to the understanding of the heterogeneity of degenerative RPE cells and highlighting SERPINE3 as a protective factor with therapeutic potential for macular atrophy.

Hui-Rong Li, Takerra K. Johnson-Stephenson, Vincent P. Kunze et al. · Journal of Clinical Investig... · 0 citations