Discovery and Biosynthesis of Brasilanes G−L: N -Acetylglucosamine-Decorated Sesquiterpenoids with Anti-Inflammatory Activity
N-Acetylglucosamine (GlcNAc)-decorated natural products represent a structurally unique class of metabolites that possess diverse biological activities. Through the genome mining of Coccidioides sp. CMB-TN39F, we identified a GlcNAc transferase-encoding terpene synthase gene cluster brc. Heterologous expression of th...