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Wen-Dong Xu

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Sep 2026

Dapagliflozin Ameliorates Pulmonary Arterial Hypertension-Induced Right Heart Failure via Ketone Body Metabolism and Mitochondrial Function Enhancement.

BACKGROUND Pulmonary arterial hypertension (PAH)-induced right ventricular (RV) failure increases reliance on ketones. The efficacy of SGLT2 inhibitors, known to modulate ketone metabolism, in this context remains unclear. METHODS A PAH model was established in Sprague-Dawley rats via a single intraperitoneal injecti...

Wen-Dong Xu, Jia Liu, Long-Long Yan et al. · 0 citations

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