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Wen-Feng Ye

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Review Open access Aug 2026

Molecular innate immune programs of tumor-associated macrophages in immune checkpoint blockade resistance: a staged framework from suppressive circuitry to translational bottlenecks

This review discusses TAM-mediated resistance to ICB as a molecularly regulated innate immune process that is dynamic and adaptive, and proposes that future TAM-directed therapies should move beyond broad macrophage depletion or nonspecific suppression and be matched to dominant macrophage programs, informed by spatial...

Yu-Zhe Huang, Jun-Qi Zhang, Kaipeng Tu et al. · 0 citations

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