Regulation of tumor angiogenesis: Roles of lncRNAs in molecular signaling, microenvironmental remodeling, and anti-angiogenic therapy.
ABSTRACT Angiogenesis is a crucial step in the growth and metastasis of invasive tumors. Tumor-induced angiogenesis is not due to a single factor; it involves activation of oncogenic signaling pathways and abnormal expression of angiogenesis-related genes within the complex tumor microenvironment (TME). Traditional res...