Wen-Han Geng

Targeting ferroptosis as a new paradigm for overcoming sorafenib resistance in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC), the most prevalent primary liver malignancy, is characterized by a rising global incidence, dismal prognosis, and high mortality rates attributed to its complex etiology and therapeutic resistance. Sorafenib, the first approved systemic therapy for advanced HCC, is limited by the rapid e...