Author

Wen-Han Lin

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Sep 2026

Anti-microbial diterpene alkaloids from the marine sponge Agelas nakamurai.

A chemical investigation of the CH2Cl2 extract of a sponge Agelas nakamurai guided by the molecular networking approach resulted in the isolation of 7 undescribed N-methylpurine diterpene alkaloids, namely nakamuranine A-G (1-7), in addition to (+)-8-epiagelasine T, agelasine D and (+)-agelamide D. Their structures wer...

Ruo-Feng Sun, Shang Chen, W. Cheng et al. · Bioorganic chemistry (Print) · 0 citations

Review Open access Aug 2026

Challenges and Emerging Strategies in Marine Natural Product Discovery and Drug Development

Marine natural products provide a unique source for pharmaceutical applications to treat patients with serious diseases, owing to diverse chemical scaffolds that endow them with novel modes of action. During the research and development of marine medicines, the discovery of bioactive compounds from marine origins is a...

Wen-Han Lin, Ke Ma, Yi-Ning Wang et al. · MarineMedicine · 0 citations