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Wen-Hua Tan

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Open access Aug 2026

Single-Cell Transcriptome Analysis Reveals IRF1-Driven Epithelial States and Glycosaminoglycan–Glycolysis Coupling in Cisplatin-Resistant HGSOC

Cisplatin resistance in HGSOC is encoded in discrete IRF1-driven epithelial states that are supported by specific TME communication networks and a glycosaminoglycan–glycolysis metabolic axis, which yields testable biomarkers and therapeutic targets for overcoming platinum resistance in ovarian cancer.

Zhaoyang Jia, Wen-Jing Pan, Xibo Zhao et al. · 0 citations

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