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Author

Wen-Hua Zheng

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3 papers indexed here

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Aug 2026

Artemisinin Attenuates Aβ1-42 Aggregation via the CaMK IV/PKA-CREB-Ace-H4 Cascade in Neuronal Cultures and 3xTg-AD Models.

Alzheimer's disease (AD), a progressive neurodegenerative disease with a rising global prevalence, is characterized by amyloid-β (Aβ) aggregation, tau hyperphosphorylation, inflammation, oxidative damage, and neuronal apoptosis. Studies have increasingly recognized epigenetic modifications as key regulators in the deve...

Yi-Tian Chen, Li-Jun Ge, Philip Lazarovici et al. · 0 citations
Sep 2026

Artemether alleviates Aβ1-42-induced neuronal cell damage via PGC-1α-mediated mitochondrial homeostasis in Alzheimer's disease.

BACKGROUND Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide and the leading cause of dementia. Mitochondrial dysfunction is a key pathogenic event that drives neuronal damage and disease progression. Thus, protecting against mitochondrial damage in neuronal cells has become a critical th...

Jun Cai, Jing Luo, Yong-Gui Cai et al. · 0 citations
Sep 2026

Artemisinin Activates AMPK to Rescue Neuronal Cells and 3xTg Mice from Aβ1-42 Neurotoxicity.

It is demonstrated that ART confers robust neuroprotection primarily via AMPK activation, thereby restoring redox homeostasis, preserving mitochondrial structural integrity, and suppressing caspase-dependent apoptosis.

Yi-Tian Chen, Wen-Jun Xiong, Li-Jun Ge et al. · 0 citations

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