Open access
Sep 2026
Structure and mechanism of HDV ribozymes revealing Lewis acid catalysis by a metal ion
We have determined the molecular structure and investigated the catalytic mechanism of two ribozymes of the Hepatitis delta virus family, found in the nematode Caenorhabditis briggsae and virus Ackermannviridae . Crystal structures of both conform to the double-pseudoknot architecture adopted by the viral HDV r...
Yu-Hang Luo, Xiao-Xue Chen, Xiao-Wei Lin et al.
· Nature Communications · 0 citations