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Author

Wen-Jie Chen

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Sep 2026

A multi-omics Mendelian randomization study identifies putatively causal genes and pathways for Alzheimer's disease associated with reactive astrocytes.

BackgroundNeuroinflammation, particularly involving reactive astrocytes, plays a pivotal role in Alzheimer's disease (AD) progression.ObjectiveHowever, the causal genes and regulatory pathways linking astrocyte reactivity to AD risk remain unclear.MethodsWe performed a multi-omics summary-data-based Mendelian randomiza...

Qi Zhu, Wen-Jie Chen, Xu Han · 0 citations
Open access Sep 2026

OLR1 as a Key Inflammatory Regulator Associated with Poor Response to Neoadjuvant Immunochemotherapy in Resectable Lung Cancer

Targeting OLR1 may represent a promising strategy to enhance immunotherapy efficacy and improve clinical outcomes in patients with resectable lung cancer, but the study is limited by a relatively small validation cohort and a strong reliance on bioinformatics analyses.

Xin-Xian Chen, Siang Zhang, Xue-Feng Ai et al. · 0 citations

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