Author

Wen-Jin Zhang

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Open access Sep 2026

Pangenome-resolved polymorphic transposable elements reveal human regulatory evolution in action

Transposable elements are a major source of gene-regulatory functions. Yet this contribution is understood largely from ancient insertions already fixed in the genome: the successes, seen long after the fact. The polymorphic phase before fixation or loss remains poorly resolved because such alleles could be scored only...

Juan Jiang, X. Zhuo, Rong-Han Li et al. · bioRxiv · 0 citations

Open access Aug 2026

Human panepigenome represents epigenomic diversity

The human pangenome captures genetic diversity beyond a single linear reference, yet conventional DNA methylome maps largely assume that the underlying CpG substrate is fixed. Here we present a first draft of the human panepigenome on DNA methylation, generated from 440 haplotype-resolved long-read methylomes spanning...

Zheng Dong, Juan F. Macias-Velasco, X. Zhuo et al. · bioRxiv · 0 citations