ROS-xCT metabolic coupling defines an astrocyte subtype that drives glutamate excitotoxicity during Alzheimer's disease progression.
AIMS This study aims to systematically identify the cellular drivers of brain microenvironmental imbalance during Alzheimer's disease (AD) progression by integrating high-resolution single-nucleus RNA sequencing (snRNA-seq) with intercellular communication analyses. In the work, the functional transitions and metabolic...