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Wen-Jing Sun

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Aug 2026

Combinatorial Lid-Domain Engineering and Computational Design Enable Simultaneous Enhancement of Activity and Thermostability of D-Allulose 3-Epimerase.

d-Allulose is a promising low-calorie rare sweetener; however, its industrial production is limited by the insufficient catalytic activity and thermostability of d-allulose 3-epimerases (DAEases). In this study, a combinatorial engineering strategy integrating lid-domain modulation and computational design was develope...

Qi-Chen Liu, Xin-Rui Tang, Wen-Jing Sun et al. · 0 citations
Aug 2026

Parallel Multidimensional Engineering of Acetylxylan Esterase Enables Concurrent Enhancement of Thermostability and Catalytic Efficiency.

Simultaneously enhancing the thermostability and catalytic activity of acetylxylan esterases (AxEs) remains a significant challenge due to the inherent stability-activity trade-off. Here, a previously uncharacterized CE7 family acetylxylan esterase (TsAxE) from Thermoclostridium stercorarium was identified and engineer...

Yu-Jiao Tao, Xin-Rui Tang, Mei Zhao et al. · 0 citations
Open access Jun 2026

Deciphering the genetic background of an industrial 2-ketogluconic acid-producing strain Pseudomonas plecoglossicida JUIM01 using whole-genome sequencing.

The genetic determinants hypothetically linked to efficient 2KGA synthesis, including glucose metabolism, fatty acid metabolism, and the oxidative phosphorylation system are delineated, which could provide the genomic resource for elucidating high productivity and robustness, and rationally engineering the high-perform...

Lulu Li, Lei Sun, Xin-Yi Zan et al. · 0 citations

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