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Wen-Jing Yan

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Review Open access Sep 2026

Engineering Small Extracellular Vesicles for Colon-Targeted Delivery: Microenvironment-Responsive Design, Therapeutic Mechanisms, and Clinical Translation

Abstract Small extracellular vesicles (sEVs) are endogenous lipid-bilayer nanovesicles that combine cargo protection, biological membrane compatibility, and modifiable surface recognition. For colon-targeted delivery, their value depends on engineering them to withstand gastric acidity and proteolysis, negotiate the mu...

Guo-Qing Liu, Mei Li, Jia-Yu Liu et al. · 0 citations

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