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Wen-Kai Liu

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Sep 2026

Function-Guided Tunnel Remodeling Enables Regioselective Synthesis of Hydroxysalidroside via Engineered Microbial UDP-Glycosyltransferase with Record Productivity

Regioselective glycosylation of polyhydroxylated natural products remains a major bottleneck for deploying glycosyltransferases in sustainable biomanufacturing. Herein, we developed a function-guided substrate tunnel remodeling strategy to redesign a microbial UDP-glycosyltransferase from Bacillus paralicheniformis (...

De He, Han-Lin Zhang, Wen-Kai Liu et al. · 0 citations

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