Author

Wen Li

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Open access Sep 2026

Integrating network analysis and machine learning to explore the pharmacological targets and associations of oleanolic acid in lung adenocarcinoma

Lung adenocarcinoma (LUAD), a major type of non-small cell lung cancer, has high incidence and mortality rates. Oleanolic acid (OA), a natural pentacyclic triterpene compound, has demonstrated potential anti-tumor effects but its pharmacological effects in LUAD remain unclear. This study aims to identify the...

Ying Zeng, Hong-Ting Jiang, Fei Zhang et al. · Frontiers in Pharmacology · 0 citations

Open access Aug 2026

Mut-p53 acts as a synthetic lethal partner with E2F3 inhibition in gastric cancer under FGFR1 inhibitor.

BACKGROUND Gastric cancer frequently harbors TP53 mutations, posing a challenge for therapies directly targeting mutant p53. Fibroblast growth factor receptor 1 (FGFR1) is a potential therapeutic target, but its interaction with mutant p53 in gastric cancer remains poorly understood. METHODS We evaluated our newly de...

Si-Jia Zhong, Fanxi Meng, Leyu Wan et al. · Cellular Signalling · 0 citations